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New NLP Method Enhances Early Autism Prediction from Clinical Notes

Clinical notes often contain important descriptive findings not captured in structured EHR fields, making them valuable for early autism prediction. However, identifying autism-related insights is difficult due to their sparsity within the large volume of notes for a typical child. Duke researchers, including Computational Biology & Bioinformatics student Fengnan Li, AI Health Data Science Fellow Elliot Hill, and Duke AI Health Data Science Fellowship Director Matthew Engelhard, PhD have developed a new natural language processing method, IRIS (Interpretable Retrieval-Augmented Classification for long Interspersed Document Sequences), to address this challenge. Their work was recently published at the 2025 Annual Meeting of the Association for Computational Linguistics.

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