Given the rapid growth in and importance of harnessing health data as a tool, Mary Klotman, MD, Dean, Duke University School of Medicine, recently announced the key leadership appointment of Michael Pencina, PhD, Vice Dean for Data Science for the School of Medicine, as the Director of Duke AI Health effective October 13, 2021. Designed as a multidisciplinary initiative, AI Health intends to unlock the enormous opportunity to spur collaborations that will leverage knowledge and expertise from across campus.