Housed within the School of Medicine but drawing leadership, resources, and insights from across the entire University, AI Health’s executive leadership combines clinical knowledge and quantitative insight. AI Health is led by Duke School of Medicine Vice Dean for Data Science Michael J. Pencina, PhD with co-director Richard Shannon, MD, the Chief Quality Officer for Duke Health. They are joined by Chief AI Health Scientist Ricardo Henao, PhD, an expert in machine learning, and Managing Director Shelley Rusincovitch, MMCi, an informaticist and technical leader. Under their guidance, AI Health constitutes a key pillar of a strategic initiative devoted to growing ethical and equitable data science and addressing the most urgent and difficult challenges in medicine and population health.